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SB 242084 hydrochloride

CAS No. 1049747-87-6

SB 242084 hydrochloride ( SB-242084 hydrochloride )

Catalog No. M10240 CAS No. 1049747-87-6

SB 242084 is a potent, selective, brain penetrant 5-HT2C receptor antagonist.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    SB 242084 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    SB 242084 is a potent, selective, brain penetrant 5-HT2C receptor antagonist.
  • Description
    SB 242084 is a potent, selective, brain penetrant 5-HT2C receptor antagonist with pKi of 9.0, 100- and 158-fold selectivity over the closely related 5-HT2B and 5-HT2A subtypes; also displays >100-fold selectivity over a range of other 5-HT, dopamine and adrenergic receptors; inhibits 5-HT-stimulated phosphatidylinositol hydrolysis with pKb of 9.3 in cell-baed assays; potently inhibits m-chlorophenylpiperazine (mCPP)-induced hypolocomotion in rats, with an ID50 of 0.11 mg/kg i.p., and 2.0 mg/kg p.o.
  • Synonyms
    SB-242084 hydrochloride
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    1049747-87-6
  • Formula Weight
    467.80
  • Molecular Formula
    C21H19ClN4O2 2HCl
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC1=NC=CC=C1OC(N=C2)=CC=C2NC(N3CCC4=C3C=C(Cl)C(C)=C4)=O.Cl.Cl
  • Chemical Name
    1H-Indole-1-carboxamide, 6-chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-, hydrochloride (1:2)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bromidge SM, et al. J Med Chem. 1997 Oct 24;40(22):3494-6.
2. Kennett GA, et al. Neuropharmacology. 1997 Apr-May;36(4-5):609-20.
3. Di Matteo V, et al. Neuropharmacology. 1999 Aug;38(8):1195-205.
4. Higgins GA, et al. Br J Pharmacol. 2001 Jun;133(4):459-66.
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